The Current Status of Diphenylhydantoin in Heart Disease

Review1 November 1967The Current Status of Diphenylhydantoin in Heart DiseaseEDWARD N. MERCER, B.A.SC., M.D., F.R.C.P.(C), JOHN A. OSBORNE, B.SC., M.D.EDWARD N. MERCER, B.A.SC., M.D., F.R.C.P.(C), JOHN A. OSBORNE, B.SC., M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-67-5-1084 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDiphenylhydantoin sodium (Dilantin®) is being widely investigated for the treatment of cardiac arrhythmias. The drug appears to offer some advantages, particularly with regard to safety, over other forms of drug therapy. Nonetheless, its use carries certain hazards, some of which may not be widely appreciated. The range of therapeutic usefulness of the drug in heart disease is becoming established, and its mode of action, although not yet fully elucidated, is undergoing intensive investigation. 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Author, Article, and Disclosure InformationAffiliations: Vancouver,From Vancouver General Hospital and The University of British Columbia, Vancouver, British Columbia, Canada.Dr. Mercer was supported in this study by a medical research fellowship from the Canadian Heart Foundation, Toronto, Ontario.Requests for reprints should be addressed to John A. Osborne, M.D., Director of Cardiology, Vancouver General Hospital, Vancouver 9, British Columbia, Canada.*Diphenylhydantoin (Dilantin®) is approved by the U. S. Food and Drug Administration for use only as an anticonvulsant; at present in the United States the use of this drug in the treatment of cardiac arrhythmias is investigational only. 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