Key result
High-sensitivity cardiac troponins expedite the evaluation of chest pain and myocardial injury, but require appropriate interpretation to avoid harmful misdiagnosis.
Why the study?
High-sensitivity cardiac troponins are a double-edged sword if not interpreted appropriately, and misdiagnosis is harmful to patient outcomes.
This review highlights the importance of appropriate interpretation of high-sensitivity troponins to avoid misdiagnosis and improve patient outcomes in acute clinical settings.
High-sensitivity cardiac troponins expedite the evaluation of patients with chest pain in the emergency department. The utility of troponins extends beyond the acute coronary syndromes to accurate the diagnosis of myocardial injury. Troponins are best friends for physicians; however, they are a double-edged sword if not interpreted appropriately. Misdiagnosis is harmful with regard to patient outcomes. The present review focuses on the recent updates in the understanding and interpretation of high-sensitivity troponins in various acute clinical settings. Common mistakes and gray zones in the interpretation of troponins, the concept of myocardial injury versus infarction, newer entities like myocardial infarction (MI) with Nonobstructive Coronary Arteries, recent controversies over the definition of periprocedural MI, complementary role of imaging in the diagnosis of myocardial injury and the role of troponins in the current COVID-19 pandemic are discussed.
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Palaparti et al. (2023) conducted a review in Chest pain and myocardial injury. High-sensitivity cardiac troponins was evaluated. High-sensitivity cardiac troponins expedite the evaluation of chest pain and myocardial injury, but require appropriate interpretation to avoid harmful misdiagnosis.
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