Key result
Androgenic status exerts site-specific control over adipogenesis and mitogen-activated protein kinase/c-fos signaling pathways in rat preadipocytes.
Rat findings on androgen effects in preadipocytes should not change practice; leaves open human validation of depot-specific mechanisms.
In rats, castration induces a complete defective adipose conversion of preadipocytes from the epididymal fat depots (Lacasa, D., B. Agli, D. Noynarol, and Y. Giudicelli, 1995, Endocrine 3: 789–793). The aim of this study was to establish the eventual site-specificity of this effect as well as the mechanisms involved.
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D. Lacasa (1997) studied this question. Androgenic status exerts site-specific control over adipogenesis and mitogen-activated protein kinase/c-fos signaling pathways in rat preadipocytes.
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