Cell Proliferation in Newly Transplanted Ehrlich Ascites Tumor Cells

Ehrlich ascites tumor cells collected from donor mice on the 5th day after inoculation were injected into the peritoneal cavity of new recipient mice. Cell cycle times were drastically shortened by transplantation, for instance, the length of the cell cycle from 47 to 21.5 hr, and the duration of S from 26.5 to 16.5 hr. Transplantation also caused a transient delay of cells in G 2 followed by a rapid acceleration and produced an immediate increase in the number of cells in DNA synthesis by about 5–8%.