Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
June 1, 1980Journal of Biological ChemistryOpen Access

Regulation of low density lipoprotein receptors by adrenocorticotropin in the adrenal gland of mice and rats in vivo.

View Full Paper
Ask AI
Bookmark
Share

Authors

PKPetri T. KovanenPreventive CardiologyJoseph L. GoldsteinJoseph L. GoldsteinThe University of Texas Southwestern Medical CenterDCDavid ChappellUniversity of Iowa

Discussion

Loading...

Member takes

Implication

Randomized trial demonstrates LDL receptor regulation by ACTH in adrenal glands, suggesting cholesterol uptake implications.

Key Points

  • The aim is to investigate how ACTH affects LDL receptor regulation in the adrenal glands of mice and rats.
  • Membranes from adrenal glands were prepared from mice and rats to examine LDL binding sites.
  • Animals were treated with adrenocorticotropin (ACTH) and monitored for changes in LDL uptake and receptor sites.
  • Preventive effects of dexamethasone on ACTH-induced LDL binding site increases were also assessed.
  • The number of LDL binding sites per mg of membrane protein increased 2- to 5-fold within 24 hours after ACTH treatment.
  • In mice and rats rendered lipoprotein-deficient, LDL binding sites increased by 5-fold; this was prevented by dexamethasone.
  • ACTH treatment enhanced the adrenal uptake of intravenously administered 125I-LDL, indicating active LDL mediation.

Cite This Study

Kovanen et al. (1980) studied this question.

synapsesocial.com/papers/6a20862d47fdc8d429f42714https://doi.org/10.1016/s0021-9258(19)70671-1
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Low Density Lipoprotein Receptors in Bovine Adrenal Cortex. I. Receptor-Mediated Uptake of Low Density Lipoprotein and Utilization of Its Cholesterol for Steroid Synthesis in Cultured Adrenocortical Cells*1979 · 164 citations
  2. 2PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT1951 · 318,728 citations
  3. 3Low Density Lipoprotein Receptors in Bovine Adrenal Cortex. II. Low Density Lipoprotein Binding to Membranes Prepared from Fresh Tissue*1979 · 172 citations
  4. 4Regulation of cholesterol synthesis in rat adrenal gland through coordinate control of 3-hydroxy-3-methylglutaryl coenzyme A synthase and reductase activities.1977 · 96 citations
  5. 5The Low-Density Lipoprotein Pathway and its Relation to Atherosclerosis1977 · 2,467 citations