Key result
A multicompartment computational model demonstrated that alveolar O2 uptake kinetics are nonexponential, nonlinear distortions of muscle O2 uptake kinetics explained by circulatory interactions.
A novel multicompartment computational model demonstrates that alveolar oxygen uptake kinetics are nonexponential, nonlinear distortions of muscle oxygen uptake kinetics during exercise.
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May alter interpretation of pulmonary VO2 kinetics in exercise studies; leaves open in vivo validation of circulatory distortions.
Benson et al. (2013) studied Healthy. Multicompartment computational model (MCM) was evaluated on Kinetics of alveolar O2 uptake (Vo2A) and muscle O2 uptake (Vo2m). A multicompartment computational model demonstrated that alveolar O2 uptake kinetics are nonexponential, nonlinear distortions of muscle O2 uptake kinetics explained by circulatory interactions.
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