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August 1, 1984Transplantation16 citations

A Monoclonal Antibody Detecting a New Human T Cell Antigen, Huly-M2

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PTPeter J. ThurlowThe Royal Melbourne HospitalKLK. Erin LoveringThe Heart Research InstituteIMIan F. C. McKenzieMayo Clinic in Florida

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Abstract

HuLy-m2 is a new T cell antigen detected by a monoclonal antibody. The antibody (anti-HuLy-m2) reacts with 85% of human T cells, 20% B cells, and 50% null cells in peripheral blood. The antibody is cytotoxic, binds protein A, and is of the IgG2a subclass. HuLy-m2 antigen consists of a glycoprotein dimer Mr 37,000 subunit structure, in which sialic acid and carbohydrate play some role in antigenicity. Capping studies showed the HuLy-m2 antigen to be distinct from the previously described OKT-3, 4, 8, HuLy-m1 (OKT11), and HuLy-m3 antigens.

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Cite This Study

Thurlow et al. (1984) studied this question.

synapsesocial.com/papers/6a208a24de5eb88fb8301ceehttps://doi.org/10.1097/00007890-198408000-00010
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