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In isolated perfused rat hearts, the half-maximal AMPK activation was 1.8 ± 0.3 μM AMP despite high [ATP], suggesting reduced ATP antagonism of AMPK activation in vivo.
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The study demonstrates that in the intact rat heart, AMPK is activated at low AMP concentrations despite high ATP levels, suggesting reduced ATP antagonism in vivo compared to in vitro models.
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Frederich et al. (2002) studied this question. Bromo-octanoate and amino-oxyacetate vs. No inhibitor or inhibitors plus butyrate was evaluated on Relationship between AMPK activity and cytosolic [AMP]. In isolated perfused rat hearts, the half-maximal AMPK activation was 1.8 ± 0.3 μM AMP despite high [ATP], suggesting reduced ATP antagonism of AMPK activation in vivo.
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