Key result
Thrombomodulin was expressed in the stromal cells of 82.6% of cardiac myxomas, and calretinin in 73.9%, while all tumors were negative for c-kit, suggesting their utility as diagnostic aids.
Cross-Sectional (n=23)
Thrombomodulin and calretinin may be important diagnostic aids for cardiac myxoma, which do not express embryonic/fetal endothelial antigens like c-kit.
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May aid myxoma diagnosis in select cases; leaves open prospective validation of diagnostic accuracy.
Acebo et al. (2001) conducted a cross-sectional in Cardiac myxoma (n=23). Immunohistochemical expression of thrombomodulin, calretinin, and c-kit was evaluated on Immunoreactivity for thrombomodulin, calretinin, and c-kit. Thrombomodulin was expressed in the stromal cells of 82.6% of cardiac myxomas, and calretinin in 73.9%, while all tumors were negative for c-kit, suggesting their utility as diagnostic aids.