Key result
The geometric mean titer of anti-HEV71 antibodies was significantly higher in preschool children (GMT 46.8) than in formal school-aged children (GMT 28.8, p=0.002), indicating transmission occurs largely in preschools.
Cross-Sectional (n=856)
No
Absolute Event Rate: 46.8% vs 28.8%
p-value: p=0.002
HEV71 infection is common in Singapore children and is acquired largely during preschool years, suggesting that public health control measures should focus on preschool centers.
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Supports preschool-focused HEV71 control in Singapore; cross-sectional data leave intervention effects unproven.
Ooi et al. (2002) conducted a cross-sectional in Human Enterovirus 71 (HEV71) infection (n=856). Preschool age (2-5 years) vs. Formal school age (6-12 years) was evaluated on Geometric mean titer (GMT) of anti-HEV71 antibodies (p=0.002). The geometric mean titer of anti-HEV71 antibodies was significantly higher in preschool children (GMT 46.8) than in formal school-aged children (GMT 28.8, p=0.002), indicating transmission occurs largely in preschools.