Population
Skeletal muscle feed arteries (SMFAs) from 16 humans (mean age 63 ± 5 years, range 41–89 years)
Comparison
Capsaicin (TRPV1 agonist) vs Control (without capsaicin)
Design
Preclinical
Key result
Capsaicin significantly attenuated maximal vasocontraction in response to phenylephrine (21% vs 52% LTmax) and dexmedetomidine, while enhancing maximal vasorelaxation with ACh.
Authors
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TRPV1 activation may modulate vascular tone ex vivo; leaves open translation to human cardiovascular outcomes.
Absolute Event Rate: 21% vs 52%
Human skeletal muscle feed arteries express functional TRPV1 channels that modulate vascular function by opposing alpha-adrenergic vasocontraction and potentiating endothelium-dependent vasorelaxation.
Ives et al. (2017) studied this question. Capsaicin vs. Control (without capsaicin) was evaluated on Maximal vasocontraction in response to phenylephrine. Capsaicin significantly attenuated maximal vasocontraction in response to phenylephrine (21% vs 52% LTmax) and dexmedetomidine, while enhancing maximal vasorelaxation with ACh.