Key result
Inhibition of NO synthase with L-NOARG induced contractions in isolated rat basilar arteries, demonstrating that endothelium-derived NO suppresses spontaneous contraction and vasomotion.
Population
Isolated rat basilar arteries
Comparison
NO synthase inhibition and various antagonists vs D-NOARG, de-endothelialized arteries, and…
Design
Preclinical
Authors
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Does not inform human cerebrovascular management; leaves open translational relevance of NO suppression of vasomotion.
Endothelium-derived NO suppresses spontaneous contraction and vasomotion in rat basilar arteries, while endogenous vasoconstrictors may act as trigger factors rather than direct causes of contraction following NO synthase inhibition.
Hempelmann et al. (1998) studied Cerebral vasospasm. NO synthase inhibition (L-NOARG) vs. D-NOARG / baseline was evaluated on Contractions and spontaneous vasomotion. Inhibition of NO synthase with L-NOARG induced contractions in isolated rat basilar arteries, demonstrating that endothelium-derived NO suppresses spontaneous contraction and vasomotion.
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