SummaryGross steatorrhea has been induced experimentally in healthy human subjects by administration of a resin capable of sequestering bile acids in the intestinal lumen. This agent (MK-135) inhibited absorption of I131-labeled triolein but not I131-labeled oleic acid. In contrast to certain other forms of experimental malabsorption, MK-135-induced steatorrhea appears to be predictable and innocuous.
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Hashim et al. (1961) studied this question.
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