Key result
Higher ambulatory blood pressure levels and a nondipping circadian pattern were associated with greater leukoaraiosis volume after controlling for office blood pressure (P≤0.009).
Why the study?
Are ambulatory blood pressure levels and circadian patterns associated with ischemic brain injury (leukoaraiosis) in adults with a family history of essential hypertension?
Cross-Sectional (n=610)
Are ambulatory blood pressure levels and circadian patterns associated with ischemic brain injury (leukoaraiosis) in adults with a family history of essential hypertension?
p-value: p=≤0.009
Ambulatory blood pressure monitoring, particularly identifying nondipping patterns, provides additional prognostic information beyond office blood pressure for subclinical ischemic brain injury.
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May support ABPM beyond office readings in familial hypertension; leaves open whether targeting nondipping reduces leukoaraiosis.
Schwartz et al. (2007) conducted a cross-sectional in Essential hypertension (n=610). Ambulatory blood pressure levels and nondipping circadian pattern vs. Lower ambulatory blood pressure levels and dipping circadian pattern was evaluated on Leukoaraiosis (cerebral white matter hyperintensities) volume on brain MRI (p=≤0.009). Higher ambulatory blood pressure levels and a nondipping circadian pattern were associated with greater leukoaraiosis volume after controlling for office blood pressure (P≤0.009).
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