Fate of Patients with Newly Diagnosed Acute Myeloid Leukemia Who Fail Primary Induction Therapy
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Discussion
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Implication
Randomized trial reports survival outcomes in patients with newly diagnosed acute myeloid leukemia, suggesting early transplant importance.
Key Points
- To describe the outcomes of patients with newly diagnosed acute myeloid leukemia who did not achieve remission during primary induction therapy.
- Analyzed a cohort of 589 patients from trial S0106, focusing on outcomes of those who failed to achieve remission.
- Outcomes were assessed based on survival rates of patients receiving and not receiving allogeneic hematopoietic cell transplants.
- 4-year survival rate for the 150 analyzed patients was 23%.
- Among 64 transplanted patients, 4-year survival was 48%; for 86 non-transplanted patients, it was only 4%.
- No significant outcome differences were noted based on remission status or other variables among transplanted patients.
Cite This Study
Othus et al. (2014) studied this question.