Key result
Deep neural network aggregation on OCT data achieves ~88% accuracy in detecting schizophrenia.
Why the study?
A definitive biomarker for schizophrenia has not been identified, but retinal morphology assessed via optical coherence tomography represents a promising candidate.
Does the aggregation of 1D CNN classification results using OCT data improve the accuracy of schizophrenia detection compared to individual classifiers?
Cross-Sectional (n=120)
No
Does the aggregation of 1D CNN classification results using OCT data improve the accuracy of schizophrenia detection compared to individual classifiers?
Aggregation of deep learning classification results based on retinal OCT data improves the automatic detection of schizophrenia compared to individual classifiers.
Answers are grounded in this paper and cite their sources.
May aid OCT-based schizophrenia detection; leaves open prospective validation before clinical use.
Schizophrenia is a serious mental disorder with a complex neurobiological background and a well-defined psychopathological picture. Despite many efforts, a definitive disease biomarker has still not been identified. One of the promising candidates for a disease-related biomarker could involve retinal morphology , given that the retina is a part of the central nervous system that is known to be affected in schizophrenia and related to multiple illness features. In this study Optical Coherence Tomography (OCT) data is applied to assess the different layers of the retina. OCT data were applied in the process of automatic differentiation of schizophrenic patients from healthy controls. Numerical experiments involved applying several individual 1D Convolutional Neural Network-based models as well as further using the aggregation of classification results to improve the initial classification results. The main goal of the study was to check how methods based on the aggregation of classification results work in classifying neuroanatomical features of schizophrenia. Among over 300, 000 different variants of tested aggregation operators, a few versions provided satisfactory results.
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Karczmarek et al. (2024) conducted a cross-sectional in Schizophrenia (n=120). Deep neural networks with Quadrature-Inspired Smooth Choquet Integral aggregation of OCT data vs. Individual deep neural network classifiers was evaluated on Classification accuracy for differentiating schizophrenia patients from healthy controls. Combining deep neural network outputs with a Quadrature-Inspired Smooth Generalized Choquet Integral aggregation function achieved an 87.92% accuracy in detecting schizophrenia from OCT data.
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