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April 13, 2021Annual Review of Genomics and Human Genetics156 citationsOpen Access

The Emergence and Global Spread of Noninvasive Prenatal Testing

VRVardit RavitskyMRMarie‐Christine RoyHHHazar Haidar

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Abstract

Since its introduction in 2011, noninvasive prenatal testing (NIPT) has spread rapidly around the world. It carries numerous benefits but also raises challenges, often related to sociocultural, legal, and economic contexts. This article describes the implementation of NIPT in nine countries, each with its own unique characteristics: Australia, Canada, China and Hong Kong, India, Israel, Lebanon, the Netherlands, the United Kingdom, and the United States. Themes covered for each country include the structure of the healthcare system, how NIPT is offered, counseling needs and resources, and cultural and legal context regarding disability and pregnancytermination. Some common issues emerge, including cost as a barrier to equitable access, the complexity of decision-making about public funding, and a shortage of appropriate resources that promote informed choice. Conversely, sociocultural values that underlie the use of NIPT vary greatly among countries. The issues described will become even more challenging as NIPT evolves from a second-tier to a first-tier screening test with expanded use.

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Ravitsky et al. (2021) studied this question.

synapsesocial.com/papers/6a2093441c091fe678950eebhttps://doi.org/10.1146/annurev-genom-083118-015053
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