This review summarizes early literature on the molecular biology and pharmacology of angiotensin AT2 receptor antagonists and their potential therapeutic applications.
The primary and patent literature (through mid-1994) describing advances in AT2 receptor molecular biology and agents that interact with the angiotensin AT2 receptor subtype is reviewed. In vitro structure-activity relationships are summarised for both AT2-specific antagonists and balanced AT1/AT2 antagonists. Literature reports describing functional correlates for AT2 receptors are tabulated, and potential therapeutic utilities resulting from pharmacological intervention at AT2 receptors are discussed.
John C. Hodges (Tue,) studied this question.
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