May 24, 1994Proceedings of the National Academy of SciencesOpen Access

Neurovirulent strains of Alphavirus induce apoptosis in bcl-2-expressing cells: role of a single amino acid change in the E2 glycoprotein.

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Population

Cultured cells expressing the human bcl-2 oncogene and 2- to 4-week-old mice

Comparison

Infection with neurovirulent strains of Sindbis… vs Avirulent laboratory strain of Sindbis virus

Design

Preclinical

Authors

SUS UbolMahidol University PTPamela C. TuckerJohns Hopkins University DGDiane E. GriffinJohns Hopkins University

Discussion

Member takes

Implication

Points to glycoprotein mutations as drivers of neurovirulence; extends apoptosis research but remains preclinical.

Structured PICO

Population

Cultured cells expressing the human bcl-2 oncogene and 2- to 4-week-old mice

Intervention

Infection with neurovirulent strains of Sindbis virus or recombinant viruses with a single amino acid change in the E2 glycoprotein

Comparator

Avirulent laboratory strain of Sindbis virus

Outcome

Apoptotic cell death and neurovirulencesurrogate

A single amino acid change in the E2 glycoprotein of Sindbis virus allows it to overcome bcl-2-mediated protection against apoptosis, explaining its neurovirulence.

Cite This Study

Ubol et al. (1994) studied this question.

synapsesocial.com/papers/6a209fd25049d8f68e91ceb4 https://doi.org/10.1073/pnas.91.11.5202

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Neurovirulent strains of Alphavirus induce apoptosis in bcl-2-expressing cells: role of a single amino acid change in the E2 glycoprotein.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Neurovirulent strains of Alphavirus induce apoptosis in bcl-2-expressing cells: role of a single amino acid change in the E2 glycoprotein.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider