Answers are grounded in this paper and cite their sources.
Demonstrates rapid bacterial elimination in rat models of endocarditis, suggesting new treatment avenues.
Cpl-1, a pneumococcal phage lytic enzyme, was tested in rats with experimental endocarditis due to Streptococcus pneumoniae WB4. High-dose regimen Cpl-1 eliminated pneumococci from blood within 30 min and decreased bacterial titers in vegetations (>4 log10 CFU/g) within 2 h. Rapid bacterial lysis induced by Cpl-1 treatment increased cytokine secretion noticeably.
No takes yet. Share an insight, caveat, or question.
Entenza et al. (2005) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: