Key result
Bufalin suppressed hERG K+ currents expressed in HEK293 cells with a half-maximal inhibitory concentration of 24.83 μM and a maximal inhibitory effect of 39.45%.
May warrant arrhythmia caution with bufalin; hypothesis-generating and requires clinical validation.
In this study, we investigated the effect of bufalin on the human ether‐à‐go‐go‐related gene ( hERG ) K + channels using the perforated patch recording technique. We measured a half‐maximal inhibitory concentration ( IC 50 ) of 24.83 μ M and maximal inhibitory effect of 39.45 ± 1.14% with bufalin. These findings suggest that bufalin is a potent hERG K + channel blocker and may provide a new way for understanding Chan Su‐induced arrhythmia.
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Song et al. (2017) studied this question. Bufalin was evaluated on hERG K+ channel inhibition (IC50 24.83 μM). Bufalin suppressed hERG K+ currents expressed in HEK293 cells with a half-maximal inhibitory concentration of 24.83 μM and a maximal inhibitory effect of 39.45%.
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