Why the study?
Does citalopram inhibit HERG and L-type calcium currents in mammalian cells and guinea pig cardiomyocytes?
Does citalopram inhibit HERG and L-type calcium currents in mammalian cells and guinea pig cardiomyocytes?
Citalopram blocks HERG currents but concurrently inhibits L-type calcium currents, a mechanism that may mitigate its proarrhythmic potential and explain its relative cardiac safety.
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Concurrent L-type inhibition may offset citalopram proarrhythmia; leaves open human translation from animal data.
Witchel et al. (2002) studied this question.
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