Key result
In a computational model, reducing sodium ion conductance to 50% of its nominal value decreased the action potential upstroke from 38mV to 25mV and reduced conduction velocity.
Why the study?
Does reducing sodium ion conductance affect the amplitude and conduction velocity of the cardiac action potential in a computational model?
Does reducing sodium ion conductance affect the amplitude and conduction velocity of the cardiac action potential in a computational model?
Computational modeling demonstrates that reducing sodium ion conductance decreases the amplitude and conduction velocity of the cardiac action potential, contributing to the understanding of reentrant arrhythmias.
Does not inform clinical sodium channel modulation; leaves open computational modeling of reentrant arrhythmia mechanisms.
Sudden cardiac death is a major cause of death worldwide. In most cases, it's caused by abnormal action potential propagation that leads to cardiac arrhythmia. The aim of this article is to study the abnormal action potential propagation through sodium ion concentration variations. We use a new electrophysiological model that is both detailed and computationally efficient. This efficient model is based on the partial differential equation method. The central finite difference method is used for numerical solving of the two-dimensional (2D) wave propagation equation. Simulations are implemented in two stages, as a single cardiac cell and as a two-dimensional grid of cells. In both stages, the normal action potential formation in case of a single cell and it's normal propagation in case of a two-dimensional grid of cells were simulated with nominal sodium ion conductance. Then, the effect of sodium ion concentration on the action potential signal was studied by reducing the sodium ion conductance. It is concluded that reducing the sodium ion conductance, decreases both passing ability and conduction velocity of the action potential wave front.
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Sabzpoushan et al. (2012) studied Cardiac arrhythmia. Reduction of sodium ion conductance vs. Nominal sodium ion conductance (15 mS/cm2) was evaluated on Action potential amplitude and conduction velocity. In a computational model, reducing sodium ion conductance to 50% of its nominal value decreased the action potential upstroke from 38mV to 25mV and reduced conduction velocity.
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