An X‐linked recessive variety of ichthyosis vulgaris different from the X‐linked ichthyosis of Wells and Kerr

Pedigree analysis of ichthyosiz vulgaris in an extensive North German kindred revealed X‐linked recessive inheritance. Only males were affected; heterozygous females had no sign of this derma‐tosis. Clinically and histologically, the disease resembled the autosomal dominant form. The differential diagnosis between this X‐linked recessive ichthyosis vulgaris, ichthyosiz congenita mitis, and X‐linked ichthyosis of the Wells‐Kerr type is discussed. We conclude from our qtudy that ichthyosis vulgariz is genetically heterogeneous.