What question did this study set out to answer?

This study aims to investigate how plasma angiotensin-converting enzyme activity relates to carotid wall thickening in a healthy population.

March 1, 1994CirculationOpen Access

Plasma angiotensin-converting enzyme activity and carotid wall thickening.

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Why the study?

Is high plasma ACE activity associated with carotid wall thickening in apparently healthy older adults?

Population

160 apparently healthy subjects aged 60 to 69 years without any history of ischemic heart disease or…

Comparison

High plasma ACE activity vs Normal/lower plasma ACE activity

Design

Case-control

Authors

CBClaire Bonithon‐KoppInserm PDPierre DucimetièrePreventive Cardiology PTPierre‐Jean TouboulUniversité Claude Bernard Lyon 1

Discussion

Member takes

Implication

ACE activity linked to carotid thickening in older adults; hypothesis-generating and should not yet change practice.

Key Points

This study aims to investigate how plasma angiotensin-converting enzyme activity relates to carotid wall thickening in a healthy population.
Examined plasma ACE activity in 80 pairs of subjects without ischemic heart disease, matched for sex and presence of atheromatous plaques.
Used B-mode ultrasound to measure intimal-medial thickness in common carotid arteries among 434 men and 602 women aged 60-69.
Exclusions included subjects on lipid-lowering drugs, with further analysis subsequently conducted.
Subjects with carotid wall thickening had higher plasma ACE activity than controls (29.9 ± 7.7 U/L vs. 27.5 ± 8.0 U/L; n = 54 pairs; P < .03).
Odds ratio for carotid wall thickening based on ACE difference: 2.29 (95% CI, 1.16 to 4.52; P < .02).
Increase in plasma ACE activity was noted particularly when controlling for body mass index and smoking.

Structured PICO

Is high plasma ACE activity associated with carotid wall thickening in apparently healthy older adults?

Population

160 apparently healthy subjects (80 pairs) aged 60 to 69 years without any history of ischemic heart disease or treatment for hypertension and diabetes, selected from the EVA study.

Intervention

High plasma ACE activity

Comparator

Normal/lower plasma ACE activity

Outcome

Carotid wall thickening (intimal-medial thickness measured in the common carotid arteries by B-mode ultrasound)surrogate

Chronic exposure to high levels of plasma ACE is associated with structural changes of the arterial wall, specifically carotid intimal-medial thickening, in healthy older adults.

Cite This Study

Bonithon‐Kopp et al. (1994) studied this question.

synapsesocial.com/papers/6a20a21e01bc09701ff36f0f https://doi.org/10.1161/01.cir.89.3.952

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Plasma angiotensin-converting enzyme activity and carotid wall thickening.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Plasma angiotensin-converting enzyme activity and carotid wall thickening.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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