Historical analysis reveals the statistical foundations of randomization in clinical trials, illustrating its significance.
The history of randomized clinical trials may be traced back to the biometricians’ work and it seems to be a good example of ‘applied statistics’. On the one hand there was a direct lineage from Pearson to Bradford Hill via Fisher and Major Greenwood... On the other hand, it is not too difficult to argue for conceptual legacy, since the basic concepts grounding the choice of randomisation can be traced back to RA Fisher’s work.
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Iain Chalmers (2011) studied this question.
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