Key result
ST-segment amplitude in lead V3 was significantly correlated with the resistance index of the common carotid artery (r = 0.27-0.42, p < 0.001) in healthy Chinese adults.
Why the study?
ECG and carotid ultrasound are important tools for CVD diagnosis and prediction, but associations between ECG and carotid ultrasound parameters and the feasibility of assessing carotid health via ECG required investigation.
Does standard 12-lead ECG correlate with carotid ultrasound parameters in healthy individuals?
Cross-Sectional (n=319)
No
Does standard 12-lead ECG correlate with carotid ultrasound parameters in healthy individuals?
In healthy individuals, ST-segment amplitude on a standard 12-lead ECG correlates significantly with carotid artery resistance index, suggesting ECG could serve as a rapid screening tool for carotid health.
Answers are grounded in this paper and cite their sources.
ST V3 amplitude was associated with carotid RI; hypothesis-generating, should not yet change screening practice.
Background: Electrocardiogram (ECG) and carotid ultrasound (CUS) are important tools for the diagnosis and prediction of cardiovascular disease (CVD). This study aimed to investigate the associations between ECG and CUS parameters and explore the feasibility of assessing carotid health with ECG. Methods: This cross-sectional cohort study enrolled 319 healthy Chinese subjects. Standard 12-lead ECG parameters (including the ST-segment amplitude [STA]), CUS parameters (intima-media thickness [IMT] and blood flow resistance index [RI]), and CVD risk factors (including sex, age, and systolic blood pressure [SBP]) were collected for analysis. Participants were divided into the high-level RI group (average RI ≥ 0.76, n = 171) and the normal RI group (average RI < 0.76, n = 148). Linear and stepwise multivariable regression models were performed to explore the associations between ECG and CUS parameters. Results: Statistically significant differences in sex, age, SBP, STA and other ECG parameters were observed in the normal and the high-level RI group. The STA in lead V 3 yielded stronger significant correlations (r = 0.27–0.42, p < 0.001) with RI than STA in other leads, while ECG parameters yielded weak correlations with IMT (|r| ≤ 0.20, p < 0.05). STA in lead V 2 or V 3 , sex, age, and SBP had independent contributions ( p < 0.01) to predicting RI in the stepwise multivariable models, although the models for IMT had only CVD risk factors (age, body mass index, and triglyceride) as independent variables. The prediction model for RI in the left proximal common carotid artery (CCA) had higher adjusted R 2 (adjusted R 2 = 0.31) than the model for RI in the left middle CCA (adjusted R 2 = 0.29) and the model for RI in the right proximal CCA (adjusted R 2 = 0.20). Conclusion: In a cohort of healthy Chinese individuals, the STA was associated with the RI of CCA, which indicated that ECG could be utilized to assess carotid health. The utilization of ECG might contribute to a rapid screening of carotid health with convenient operations.
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Shi et al. (2022) conducted a cross-sectional in Healthy (n=319). ST-segment amplitude (STA) was evaluated on Correlation between ST-segment amplitude and carotid resistance index (RI) (r = 0.27-0.42, p=<0.001). ST-segment amplitude in lead V3 was significantly correlated with the resistance index of the common carotid artery (r = 0.27-0.42, p < 0.001) in healthy Chinese adults.
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