Key result
Off-bypass implantation of a self-expandable valved stent in the pulmonary position was feasible in an adult pig model, demonstrating adequate hemodynamic functioning with a mean peak pressure gradient of 6.33 mmHg.
Why the study?
Does off-bypass implantation of a self-expandable valved stent in the pulmonary position provide adequate hemodynamic functioning in an adult pig model?
Population
6 adult pigs, mean body weight 55.6 kg (range 47-67 kg)
Design
Preclinical
Follow-up
acute
Authors
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Hypothesis-generating in porcine model; leaves open human translation before any clinical consideration.
Does off-bypass implantation of a self-expandable valved stent in the pulmonary position provide adequate hemodynamic functioning in an adult pig model?
Off-bypass implantation of a large self-expandable valved stent in the pulmonary position is feasible and provides adequate acute hemodynamic function in a porcine model.
J ZHOU (2003) studied Pulmonary valve replacement (animal model) (n=6). Off-bypass implantation of a self-expandable valved stent was evaluated on Mean peak pressure gradient across the valve. Off-bypass implantation of a self-expandable valved stent in the pulmonary position was feasible in an adult pig model, demonstrating adequate hemodynamic functioning with a mean peak pressure gradient of 6.33 mmHg.
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