Key result
Vascular dysfunction, including arterial stiffness and endothelial dysfunction, is independently associated with the pathogenesis of cardiovascular disease, cognitive impairment, and depressive symptoms.
Vascular dysfunction, encompassing arterial stiffness and endothelial dysfunction, is a central mechanism linking aging and metabolic risk factors to cardiovascular disease, dementia, and depression.
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Supports vascular screening in multimorbid patients; leaves open whether interventions targeting stiffness or endothelial function improve cognitive or mood outcomes.
Vascular dysfunction may be an important pathway through which ageing and other factors, such as diabetes and obesity, can cause diseases of the heart and brain. Vascular dysfunction includes dysfunction of large arteries (due to arterial stiffness), the microcirculation (microvascular dysfunction) and endothelium (endothelial dysfunction). We have investigated, in a series of epidemiological studies, the role of vascular dysfunction in the pathogenesis of cardiovascular disease, dementia and depression. Data were used of The Hoorn Study, The AGES-Reykjavik Study, The Maastricht Study and The SUVIMAX2 Study. In addition, we did two systematic reviews and an individual participant data meta-analysis.
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Thomas T. van Sloten (2017) conducted a review in Cardiovascular disease, cognitive impairment, and depressive symptoms. Vascular dysfunction (arterial stiffness and endothelial dysfunction) was evaluated. Vascular dysfunction, including arterial stiffness and endothelial dysfunction, is independently associated with the pathogenesis of cardiovascular disease, cognitive impairment, and depressive symptoms.
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