Population
Normal rats of different ages and rats subjected to chronic aortic constriction
Comparison
Chronic aortic constriction vs Normal animals of different ages
Design
Preclinical
Authors
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Challenges myocyte-centric views of hypertrophy in rats; leaves open nonmyocyte roles in human ventricular remodeling.
In a rat model of myocardial hypertrophy, increased ventricular DNA is driven by proliferation of nonmuscle nuclei rather than polyploidy or muscle nuclei proliferation.
Grimm et al. (1970) studied this question.
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