The potential role of methanolic extract of Rhus coriaria L. on hyperglycemia, dyslipidemia and lipid peroxidation (LPO) was studied in type 2 diabetic rats. Type 2 diabetes was induced by a single intraperitoneal injection of streptozotocin (STZ, 100 mg/kg) to 2 days old rat pups. R. coriaria (200 and 400 mg/kg) was administered orally once a day for 5 weeks after the animals were confirmed diabetic (that is, 90 days after STZ injection). A group of citrate control rats were also maintained which has received citrate buffer on the 2nd day of their birth. Administration of R. coriaria extract showed a significant (P < 0.001) decrease in blood glucose and tissue MDA levels as compared to type 2 diabetic control rats. The levels of total cholesterol (TCh), triglycerides (TG), low density lipoprotein cholesterol (LDL-C) and very low density lipoproteins cholesterol VLDL-C were also significantly (P < 0.001) decreased by R. coriaria treatment when compared with type 2 diabetic control rats. In contrast the high density lipoprotein cholesterol (HDL-C) levels were significantly (P < 0.001) increased after treatment with R. coriaria extract when compared with type 2 diabetic control rats. These results revealed that R. coriaria possesses significant antihyperglycemic and antidyslipidemic activity along with potent antioxidant potential in type 2 diabetic mellitus. Key words: Antidyslipidemic, antihyperglycemic, diabetes mellitus, Rhus coriaria, streptozotocin.
No takes yet. Share an insight, caveat, or question.
Tarique Anwer (2012) studied this question.
Synapse has enriched 5 related papers. Consider them for comparative context: