Key result
Poloxamer 407 did not directly stimulate endothelial cells or macrophages in vitro, but 4-month administration in mice resulted in elevated levels of oxidized lipids in plasma.
Population
Mice (in vivo) and human umbilical vein endothelial cells and macrophages (in vitro)
Design
Preclinical
Follow-up
4 months (in vivo)
Authors
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Suggests oxidized lipids mediate murine atherosclerosis indirectly; leaves open relevance to human endothelial or macrophage activation.
Atherosclerosis induced by poloxamer 407 in mice appears to be mediated by indirect lipid oxidation rather than direct activation of endothelial cells or macrophages.
Johnston et al. (2003) studied Atherosclerosis. Poloxamer 407 (P-407) was evaluated on Endothelial cell proliferation, interleukin-6 and interleukin-8 production, nitric oxide production, and lipid oxidation. Poloxamer 407 did not directly stimulate endothelial cells or macrophages in vitro, but 4-month administration in mice resulted in elevated levels of oxidized lipids in plasma.
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