Key result
Acute resveratrol exposure does not alter fetal hemodynamics compared to baseline in sheep.
Why the study?
Studies suggest that diets high in polyphenols like resveratrol may impair fetal hemodynamics, so evaluating its safety on fetal hemodynamics was needed.
Does acute resveratrol exposure impact fetal hemodynamics in pregnant ewes?
Does acute resveratrol exposure impact fetal hemodynamics in pregnant ewes?
Acute resveratrol exposure does not alter fetal hemodynamics or oxygenation in sheep, supporting its safety profile for potential use in fetal growth restriction.
Answers are grounded in this paper and cite their sources.
Acute resveratrol leaves fetal hemodynamics unchanged in sheep; hypothesis-generating for fetal growth restriction applications.
Babies born growth restricted are at an increased risk of both poor short‐and long‐term outcomes. Current interventions to improve fetal growth are ineffective and do not lower the lifetime risk of poor health status. Maternal resveratrol (RSV) treatment increases uterine artery blood flow, fetal oxygenation, and fetal weight. However, studies suggest that diets high in polyphenols such as RSV may impair fetal hemodynamics. We aimed to characterize the effect of RSV on fetal hemodynamics to further assess its safety as an intervention strategy. Pregnant ewes underwent magnetic resonance imaging (MRI) scans to measure blood flow and oxygenation within the fetal circulation using phase contrast‐MRI and T 2 oximetry. Blood flow and oxygenation measures were performed in a basal state and then repeated while the fetus was exposed to RSV. Fetal blood pressure and heart rate were not different between states. RSV did not impact fetal oxygen delivery (DO 2 ) or consumption (VO 2 ). Blood flow and oxygen delivery throughout the major vessels of the fetal circulation were not different between basal and RSV states. As such, acute exposure of the fetus to RSV does not directly impact fetal hemodynamics. This strengthens the rationale for the use of RSV as an intervention strategy against fetal growth restriction.
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Darby et al. (2023) studied Fetal growth restriction. Resveratrol (RSV) vs. Basal state was evaluated on Fetal hemodynamics (blood flow, oxygenation, blood pressure, heart rate). Acute exposure of the fetal sheep to resveratrol did not impact fetal hemodynamics, including blood pressure, heart rate, and oxygen delivery, compared to the basal state.
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