Key result
Both rat rno-miR-466d and human hsa-miR-466 effectively down-regulated the levels of Coxsackie virus and Adenovirus Receptor (CAR) protein expression.
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miR-466 acts as a putative negative regulator of the Coxsackie virus and Adenovirus Receptor, potentially playing a role in the host antiviral response.
This study aimed at elucidating how Coxsackie B virus (CVB) perturbs the host's microRNA (miRNA) regulatory pathways that lead to antiviral events. The results of miRNA profiling in rat pancreatic cells infection models revealed that rat rno-miR-466d was up-regulated in CVB infection. Furthermore, in silico studies showed that Coxsackie virus and Adenovirus Receptor (CAR), a cellular receptor, was one of the rno-miR-466d targets involved in viral entry. Subsequent experiments also proved that both the rno-miR-466d and the human hsa-miR-466, which are orthologs of the miR-467 gene family, could effectively down-regulate the levels of rat and human CAR protein expression, respectively.
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Lam et al. (2014) studied Coxsackie B virus (CVB) infection. miR-466 (rno-miR-466d and hsa-miR-466) was evaluated on Coxsackie virus and Adenovirus Receptor (CAR) protein expression. Both rat rno-miR-466d and human hsa-miR-466 effectively down-regulated the levels of Coxsackie virus and Adenovirus Receptor (CAR) protein expression.
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