Understanding Perceived Barriers of Minority Medical Students Pursuing a Career in Dermatology

Discussion | Although the number of cases of NUC in the study is small, the condition affected a high percentage of women receiving anticoagulation therapy, adding further support to the body of evidence that sex and anticoagulant use are 2 important risk factors for NUC. Warfarin, in particular, has been hypothesized to promote NUC by inhibiting vitamin K-dependent carboxylation of matrix Gla protein, decreasing inhibition of local calcification. he estimated 1-year survival rate for all patients with calciphylaxis has previously been reported as 45.8% 5 ; and patients with ulceration fare worse, with an estimated 80% mortality. atients in the present study had a high survival rate (75%) despite the fact that all patients had ulceration. One possible reason for this improved survival rate is the frequent use of sodium thiosulfate, with 63% of patients (n = 10) in our analysis receiving this form of therapy. This finding contrasts with the 48% survival rate previously reported among NUC patients 2 ; notably, none of these patients received sodium thiosulfate, suggesting a possible benefit associated with sodium thiosulfate therapy for NUC.