Environmental Fate of Insecticidal Plant-Incorporated Protectants from Genetically Modified Crops: Knowledge Gaps and Research Opportunities

Plant-incorporated protectants (PIPs) are biopesticides expressed in genetically modified (GM) crops and are typically macromolecular in nature. First-generation insecticidal PIPs were Cry proteins expressed in GM crops containing transgenes from the soil bacterium Bacillus thuringiensis; next-generation double-stranded ribonucleic acid (dsRNA) PIPs have been recently approved. Like conventional synthetic pesticides, the use of either Cry protein or dsRNA PIPs results in their release to receiving environments. However, as opposed to conventional low molecular weight pesticides, the environmental fate of macromolecular PIPs remains less studied and is poorly understood. This Feature highlights the knowledge gaps and challenges that have emerged while investigating the environmental fate of Cry protein PIPs and suggests new avenues to advance the state of the research necessary for the ongoing environmental fate assessment of dsRNA PIPs.