We studied the effect of percutaneous ethanol injection (PEI) in the treatment of cold, cytologically benign, large (10 mL) thyroid nodules (CBNs) in 41 patients.The end-point of our study was to evaluate the efficacy of PEI on: 1) local symptomatology, assessed by an arbitrary symptom score; and 2) nodule volume and tracheal displacement (at ultrasonography).Follow-up ranged from 12-36 (21 9) months.Symptom score was significantly reduced (P 0.01) after 6 months and at the end of the follow-up (2.1 0.3 vs. 0.2 0.5 and vs. 0.2 0.4).A significant (P 0.01) nodule volume reduction was observed, without differences between solid or mixed CBNs; the reduction was 50% or more in 92.7% of patients.Neither clinical parameters nor pretreatment nodule ultrasonographic features were related to nodule reduction.
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Matteo Zingrillo (1998) studied this question.