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Demonstrates macrophage-neuron communication modulates pain in neuropathic pain conditions, suggesting new therapeutic targets.
downregulation in neurons in concomitance to attenuation of neuropathic mechanical hypersensitivity. These data suggest that, under neuropathic conditions, pro-inflammatory macrophages shuttle EV-containing miR-155 to neurons and contribute to the expression of pronociceptive IL-6 in DRG.
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Picco et al. (2024) studied this question.
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