Amyloidosis: Tissue Proteinosis: Gammaloidosis

Editorials1 December 1961Amyloidosis: Tissue Proteinosis: GammaloidosisELLIOTT F. OSSERMAN, M.D.ELLIOTT F. OSSERMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-55-6-1033 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe three articles dealing with "amyloidosis" which appear in this issue of the ANNALS are testimony to the continuing interest in this vexingly obscure clinical and experimental phenomenon. Despite the extensive studies of the subject which have been carried out over the past several decades, the precise pathogenesis and exact biochemical nature of these infiltrates are still incompletely understood. Some progress has been made, however, and it may be in order to summarize briefly our present knowledge and some of the current "working hypotheses."At the outset, it may be appropriate to examine and possibly to challenge the validity of...References1. APITZ K: Die paraproteinosen (über die Störung des Eiweisstoffwechsels bei Plasmacytom). Virchow. Arch. Path. Anat. 306: 631, 1940. CrossrefGoogle Scholar2. TEILUM G: Periodic acid-Schiff-positive reticuloendothelial cells producing glycoprotein: functional significance during formation of amyloid. Amer. J. Path. 32: 945, 1956. MedlineGoogle Scholar3. VASQUEZDIXON JJFJ: Immunohistochemical analysis of amyloid by fluorescence technique. J. Exp. Med. 104: 727, 1956. CrossrefMedlineGoogle Scholar4. MELLORSNOWOSLAWSKIKORNGOLDSENGSON RCALBL: Rheumatoid factor and the pathogenesis of rheumatoid arthritis. J. Exp. Med. 113: 475, 1961. CrossrefMedlineGoogle Scholar5. BRIGGS GW: Amyloidosis. Ann. Intern. Med. 55: 943, 1961. LinkGoogle Scholar6. OSSERMAN EF: Plasma-cell myeloma. New Engl. J. Med. 261: 952; 1006, 1959. CrossrefMedlineGoogle Scholar7. KYLEBAYRD REED: Primary systemic amyloidosis and myeloma. Arch. Intern. Med. 107: 344, 1961. CrossrefMedlineGoogle Scholar8. MAGNUS-LEVY A: Amyloidosis in multiple myeloma: progress noted in 50 years of personal observation. J. Mount Sinai Hosp. N. Y. 19: 8, 1952. MedlineGoogle Scholar9. OSSERMANTALALTAKATSUKI EFNK: Unpublished observations. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ELLIOTT F. OSSERMAN, M.D.Affiliations: Department of Medicine Columbia University College of Physicians and Surgeons Francis Delafield Hospital New York 32, New York PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAntibodies gone bad – the molecular mechanism of light chain amyloidosisKidney and liver involvement in monoclonal light chain disordersMechanisms of Disease: Monoclonal Immunoglobulin DepositionDiagnosis of the type of amyloid in paraffin wax embedded tissue sections using antisera against human and animal amyloid proteinsThe Bases of the Staining of Amyloid Fibers: Their Physico-Chemical Nature and the Mechanism of their Dye-Substrate InteractionAmyloid Deposits and AmyloidosisBiology, Clinical Patterns, and Treatment of Multiple Myeloma and Related Plasma–Cell DyscrasiasAllergic Renal DiseasesLaryngeal amyloidosisPatterns of Amyloidosis and Their Association with Plasma-Cell Dyscrasia, Monoclonal Immunoglobulins and Bence-Jones ProteinsParaproteinämische HämoblastosenAmyloid arthritis simulating rheumatoid disease in five patients with multiple myelomaAmyloidosis and multiple myelomaSemimaligne Primärtumoren der Bronchien und LungenGutartige Primärtumoren der Bronchien und LungenAmyloid Tumor of the LarynxEXPERIMENTAL AMYLOIDOSIS INDUCED BY IMMUNE COMPLEX: II. AN IMMUNOHISTOLOGICAL OBSERVATIONCase 10-1972The Changing Pattern of Diseases Associated with M ComponentsThe immunoglobulin origin of amyloidEXPERIMENTAL AMYLOIDOSIS INDUCED BY IMMUNE COMPLEX OR HEAT DENATURED DNADiffuse alveolarseptale LungenamyloidosePrimary `acquired' hypogammaglobulinaemia and amyloidosisOn the Origin of Amyloid Study of an Amyloid Tumor in Multiple MyelomaJOSEPH GAFNI, M.D., HANS-JOACHIM MERKER, M.D., SHLOMO SHIBOLET, M.D., EZRA SOHAR, M.D., HARRY HELLER, M.D.Primary amyloidosisSevere Diarrhea Controlled by Gamma Globulin in a Patient with Agammaglobulinemia, Amyloidosis, and ThymomaHAROLD O. CONN, M.D., RICHARD QUINTILIANI, M.D.SENILE CEREBRAL, PANCREATIC INSULAR AND CARDIAC AMYLOIDOSIS*Rheumatism and Arthritis Review of American and English Literature of Recent Years (Sixteenth Rheumatism Review)CHARLEY J. SMYTH, M.D., F.A.C.P., ROGER L. BLACK, M.D., CHARLES CHRISTIAN, M.D., MACK L. CLAYTON, M.D., F.A.C.S., DONALD F. HILL, M.D., F.A.C.P., JOSEPH LEE HOLLANDER, M.D., F.A.C.P., WILLIAM M. MIKKELSEN, M.D., F.A.C.P., MAX M. MONTGOMERY, M.D., F.A.C.P., CARL M. PEARSON, M.D., F.A.C.P., HUGH A. SMYTHE, M.D., F.R.C.P. (C), L. EMMERSON WARD, M.D., F.A.C.P., HOWARD J. WEINBERGER, M.D., F.A.C.P.PATHOGENESIS OF AMYLOIDOSISCorticosteroid Therapy of Amyloid Nephrotic SyndromeMORTON H. MAXWELL, M.D., F.A.C.P., DONALD A. ADAMS, M.D., RALPH GOLDMAN, M.D., F.A.C.P.THE INHERITED AMYLOIDOSES THEIR CLINICAL AND THEORETICAL SIGNIFICANCEFluorescence microscopy with thioflavine-T in the diagnosis of amyloidConnective tissue disease associated with malignant neoplastic diseaseBILLROTH AND CARDIAC SURGERYAMYLOID AND THE LYMPHOCYTECase 43-1962 1 December 1961Volume 55, Issue 6Page: 1033-1036KeywordsAmyloid proteinsAmyloidosisPathogenesis ePublished: 1 December 2008 Issue Published: 1 December 1961 PDF downloadLoading ...