Key result
Higher Dietary Inflammatory Index linked to ~12% higher cardiovascular mortality per unit increase.
Why the study?
Do higher Dietary Inflammatory Index scores and depression increase mortality risk in U.S. adults?
Observational
Do higher Dietary Inflammatory Index scores and depression increase mortality risk in U.S. adults?
Higher dietary inflammatory index scores and depression independently elevate all-cause and cardiovascular mortality risks in U.S. adults.
Associated with higher mortality; leaves open whether anti-inflammatory diets improve outcomes in U.S. adults.
METHODS: Patient Health Questionnaire-9 (PHQ-9). Logistic regression and restricted cubic spline (RCS) analyses examined DII-depression associations. Cox regression and Kaplan-Meier curves evaluated mortality risks. RESULTS: (HR:2.40, 95% CI: 1.58-3.65), and nonsmokers (HR:2.61, 95% CI: 1.77-3.85). Each unit DII increase raised all-cause mortality by 7% (HR:1.07, 95% CI:1.02-1.12) and cardiovascular diseases (CVD) mortality by 12% (HR:1.12, 95% CI:1.02-1.22), with stronger effects in those with BMI ≥ 25 (HR:1.11,95% CI:1.05-1.18) and smokers (HR:1.14,95% CI:1.05-1.23). No significant DII-depression interaction on mortality was found. CONCLUSION: A higher DII score was associated with increased depression risk in U.S. adults. Depression and high DII scores elevated all-cause mortality, but these impacts varied with age, BMI, or smoking status. These findings highlight nutrition-mental health links for targeted prevention.
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Weng et al. (2025) conducted an observational in Depression. Dietary inflammatory index (DII) was evaluated on All-cause mortality (HR 1.07, 95% CI 1.02-1.12). Each unit increase in the Dietary Inflammatory Index raised all-cause mortality by 7% (HR 1.07; 95% CI 1.02-1.12) and cardiovascular disease mortality by 12% (HR 1.12; 95% CI 1.02-1.22).
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