Key result
Depressive personality traits, specifically the neurotic triad of the MMPI-2, correlated significantly with the mRNA and protein expression of MnSOD, MPO, MMP-2, and MMP-9 in patients with depression.
Why the study?
Depression is conceptualized as an immune-inflammatory and oxidative stress disorder, but whether depressive personality traits correlate with peripheral inflammatory and oxidative balance markers remained to be determined.
Cross-Sectional (n=104)
No
Personality traits associated with the neurotic triad in depression correlate with peripheral expression of inflammatory and oxidative stress markers like MnSOD, MPO, and MMPs.
Answers are grounded in this paper and cite their sources.
No immediate change to depression care; leaves open mechanistic links between neurotic traits and oxidative/inflammatory pathways.
INTRODUCTION: Nowadays, depression is conceptualized as an immune-inflammatory and oxidative stress disorder associated with neuroprogressive changes as a consequence of peripherally activated immune-inflammatory pathways, including peripheral cytokines and immune cells which penetrate into the brain via the blood barrier, as well as nitro-oxidative stress and antioxidant imbalances. The aim of this study was to investigate whether personality traits predisposing to a depressive episode (hypochondria, dysthymic, hysteria) are associated with changes in peripheral gene expression for selected indicators of inflammation and oxidative balance. MATERIAL AND METHODS: One hundred four people meeting the diagnostic criteria specified for a depressive episode took part in the study. Selected scales of the Minnesota Multiphasic Personality Inventory (MMPI-2) were used to measure personality traits. Expression at the mRNA and protein level for manganese superoxide dismutase (MnSOD), myeloperoxidase (MPO), cyclooxygenase 2 (COX-2), inducible nitric oxide synthase (iNOS), and metalloproteinases 2 and 9 (MMP-2, MMP-9) was examined. RESULTS: Scales for the neurotic triad of the MMPI-2 test correlated significantly with the expression at the level of mRNA and protein for MnSOD, MPO and metalloproteinases 2 and 9. CONCLUSIONS: The scales specified for the neurotic triad of the MMPI-2 test correspond substantially with the expression of MnSOD, MPO and metalloproteinases 2 and 9 at the mRNA and protein levels in the group of patients suffering from depression.
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Talarowska et al. (2019) conducted a cross-sectional in Depressive episode (n=104). Depressive personality traits (neurotic triad of MMPI-2) was evaluated on Correlation between MMPI-2 neurotic triad scales and expression of inflammatory and oxidative markers (MnSOD, MPO, COX-2, iNOS, MMP-2, MMP-9). Depressive personality traits, specifically the neurotic triad of the MMPI-2, correlated significantly with the mRNA and protein expression of MnSOD, MPO, MMP-2, and MMP-9 in patients with depression.
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