Last year at this meeting Salzman et al. (1974) reviewed certain aspects of SV40 DNA replication. In brief, it was shown that (a) initiation of synthesis occurs at a specific site, (b) replication is bidirec-tional, (c) chain growth occurs by a discontinuous mechanism with the possible involvement of two polymerases, one required for synthesis of 4S frag-ments and the second involved in filling the gaps be-tween these fragments and the growing chains, and (d) a mechanism ust exist which allows for nick-ing and sealing of parental strands to permit DNA replication and yet preserves a covalently closed structure in the template strands of the replicating molecules. In this paper, findings are reported which describe
No takes yet. Share an insight, caveat, or question.
Salzman et al. (1974) studied this question.