Virtual cohorts of cardiac models are being developed to capture inter-patient variability and guide therapies, requiring robust workflows to transition from bespoke models to large-scale creation.
Patient-specific cardiac models are now being used to guide therapies. The increased use of patient-specific cardiac simulations in clinical care will give rise to the development of virtual cohorts of cardiac models. These cohorts will allow cardiac simulations to capture and quantify inter-patient variability. However, the development of virtual cohorts of cardiac models will require the transformation of cardiac modelling from small numbers of bespoke models to robust and rapid workflows that can create large numbers of models. In this review, we describe the state of the art in virtual cohorts of cardiac models, the process of creating virtual cohorts of cardiac models, and how to generate the individual cohort member models, followed by a discussion of the potential and future applications of virtual cohorts of cardiac models. This article is part of the theme issue 'Uncertainty quantification in cardiac and cardiovascular modelling and simulation'.
Niederer et al. (Sun,) conducted a review in Cardiac modelling. Virtual cohorts of cardiac models was evaluated. Virtual cohorts of cardiac models are being developed to capture inter-patient variability and guide therapies, requiring robust workflows to transition from bespoke models to large-scale creation.