Blastocyst telomere length predicts successful implantation after frozen-thawed embryo transfer

January 1, 2024Human Reproduction OpenOpen Access

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This research aims to determine whether longer telomere length in blastocysts enhances the likelihood of successful implantation after frozen-thawed embryo transfer.
Analyzed 965 blastocysts from 232 cycles at an IVF center between March 2015 to May 2018.
Used low-pass whole genome sequencing data to estimate telomere length and mitochondrial copy number for each embryo.
Applied machine learning models, including logistic regression and random forest, to assess factors associated with implantation potential.
Embryos with longer telomere lengths showed an odds ratio of 79.1 for successful implantation (p<0.01).
Classification accuracy of machine learning models was 0.82 for decision tree and 0.91 for random forest.
Combined maternal and embryo parameters indicated a significant correlation with implantation success.

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Demonstrates the role of telomere length in predicting successful embryo implantation, suggesting improved strategies for fertility treatments.

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Chien et al. (2024) studied this question.

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