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June 30, 2014Journal of Leukocyte Biology

Editorial: NK cell immune activation in HIV-1 infection: flipping the bad and good side of the same coin

Enrico Lugli Domenico Mavilio

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Abstract

Discussion of HIV-1-mediated aberrant immune activation of NK cells, and impaired host immune response as an indicator of disease progression.

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Lugli et al. (2014) studied this question.

synapsesocial.com/papers/6a20d1cd8446b104fdecaf9c https://doi.org/10.1189/jlb.4ce0114-032r

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1New Concepts in the Immunopathogenesis of HIV InfectionOriginal Research · 1995 · 317 citations
2Shorter Survival in Advanced Human Immunodeficiency Virus Type 1 Infection Is More Closely Associated with T Lymphocyte Activation than with Plasma Virus Burden or Virus Chemokine Coreceptor UsageOriginal Research · 1999 · 1,032 citations
3Immune activation and inflammation in HIV‐1 infection: causes and consequencesReview · 2007 · 743 citations
4Pathogenic Mechanisms of HIV DiseaseOriginal Research · 2011 · 463 citations
5Pathologic natural killer cell subset redistribution in HIV-1 infection: new insights in pathophysiology and clinical outcomesReview · 2010 · 93 citations

Natural Killer Cell Immunodeficiency in HIV Disease is Manifest by Profoundly Decreased Numbers of CD16 + CD56+ Cells and Expansion of a Population of CD16dim CD56- Cells with Low Lytic Activity1995
Characterization of CD56<sup>–</sup>/CD16<sup>+</sup>natural killer (NK) cells: A highly dysfunctional NK subset expanded in HIV-infected viremic individuals2005
Sequential deregulation of NK cell subset distribution and function starting in acute HIV-1 infection2005
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