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We consider the switching rate of a metastable reaction scheme, which includes reactions with arbitrary steps, e.g., kA<-->(k+r)A (both forward and reverse reaction steps are allowed to happen). Employing a WKB approximation, controlled by a large system size, we evaluate both the exponent and the preexponential factor for the rate. The results are illustrated on a number of examples.
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Escudero et al. (2009) studied this question.
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