Lung Changes During Hexamethonium Therapy for Hypertension

During the course of treating 54 severely hypertensive patients with parenteral hexamethonium bromide, we-have observed the development of unexpected pulmonary dyspnea and associated radiographic changes in the lungs in three cases after 7, 9, and 12 months' therapy respectively. Two of these came to autopsy; the third has recovered. The object of this paper is to record the clinical, radiological, and pathological aspects of these pulmonary changes.