Mitochondria in intact ventricular myocytes only take up Ca2+ when resting cytosolic Ca2+ exceeds 300-500 nM, with slower kinetics than cytosolic Ca2+ transients.
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Questions mitochondrial Ca2+ uptake during normal contractions in intact myocytes; extends isolated-organelle data but leaves open human in vivo relevance.
Zhou et al. (1998) studied this question.
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