Key result
3D tagged MRI showed hearts with right ventricular pressure overload had more septal flattening, and hypertrophic cardiomyopathy hearts had lower stress indices compared to normal hearts.
Why the study?
Does 3D tagged MRI characterize differences in cardiac shape and load between patients with HCM, RVPO, and normal subjects?
Observational
Does 3D tagged MRI characterize differences in cardiac shape and load between patients with HCM, RVPO, and normal subjects?
3D tagged MRI can effectively map curvature and stress to characterize geometric and functional differences in HCM and RVPO compared to normal hearts.
Supports 3D tagged MRI for distinguishing HCM and RVPO mechanics; hypothesis-generating and should not yet change practice.
Three dimensional (3D) reconstructions of the heart from sets of two dimensional (2D) tagged magnetic resonance imaging (MRI) cross sections, were used to characterize the 3D geometry of the left ventricles in patients with hypertrophic cardiomyopathy (HCM) and patients with right ventricular pressure overload (RVPO). Curvatures, stresses, wall thickness and endocardial motion were calculated from surface and volume elements. Hearts with RVPO exhibited more circumferential and meridional flattening of the septum than normal and HCM hearts. The stress indices were lowest in the HCM hearts, compared to normal and RVPO hearts, due to the larger thicknesses. There was a more significant difference between lateral wall motion, and other regional wall motions in the HCM and RVPO hearts as compared to normal hearts. It is suggested that curvature and stress mapping by 3D tagged MRI can be advantageously used as an important clinical tool.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
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Petrank et al. (2002) conducted an observational in Hypertrophic cardiomyopathy (HCM) and right ventricular pressure overload (RVPO). 3D tagged magnetic resonance imaging (MRI) vs. Normal hearts was evaluated on 3D geometry (curvatures, stresses, wall thickness, and endocardial motion). 3D tagged MRI showed hearts with right ventricular pressure overload had more septal flattening, and hypertrophic cardiomyopathy hearts had lower stress indices compared to normal hearts.
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