Key result
Genome-wide association analysis identified five novel signals near established lipid loci at HIF3A, ADAMTS3, PLTP, LCAT, and LIPG, and uncovered novel associations for rare coding variants at LIPC and LIPG with HDL subclasses.
Population
8,372 non-diabetic Finnish men from the METSIM study
Design
Cohort
Authors
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Hypothesis-generating for HDL biology and targets; extends GWAS loci but leaves open clinical translation pending validation.
Observational (n=8,372)
p-value: p=<5x10^-8
The identification of novel genetic variants associated with lipoprotein subclasses provides further insight into the molecular basis of dyslipidemia and potential therapeutic targets.
Davis et al. (2017) conducted an observational in Dyslipidemia / Lipid and lipoprotein subclasses (n=8,372). Genetic variants (common, low-frequency, and rare) vs. Reference alleles was evaluated on Association of genetic variants with 72 lipid and lipoprotein traits (p=<5x10^-8). Genome-wide association analysis identified five novel signals near established lipid loci at HIF3A, ADAMTS3, PLTP, LCAT, and LIPG, and uncovered novel associations for rare coding variants at LIPC and LIPG with HDL subclasses.
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